2010年～2015年　論文リスト

2015

Michio Iwaoka, Nobukazu Sano, Ying-Yin Lin, Arisa Katakura, Masato Noguchi, Kohei Takahashi, Fumio Kumakura, Kenta Arai, Beena G. Singh, Amit Kunwar, K. Indira Priyadarsini, Fatty Acid Conjugates of Water-Soluble (±)-trans-Selenolane-3,4-diol: Effects of Alkyl Chain Length on the Antioxidant Capacity. ChemBioChem, 2015, 16, pp.1226-1234.
Kenta Arai, Fumio Kumakura, Motoi Takahira, Natsumi Sekiyama, Nozomi Kuroda, Toshiki Suzuki, Michio Iwaoka, Effects of Ring Size and Polar Functional Groups on the Glutathione Peroxidase-Like Antioxidant Activity of Water-Soluble Cyclic Selenides. J. Org. Chem., 2015, 80, pp.5633-5642.

2014

Kenta Arai, Kenji Moriai, Akinobu Ogawa, Michio Iwaoka, An Amphiphilic Selenide Catalyst Behaves Like a Hybrid Mimic of Protein Disulfide Isomerase and Glutathione Peroxidase 7. Chem. Asian J., 2014, 9, pp.3464-3471. (DOI: 10.1002/asia.201402726) (Selected as back-cover picture of the issue)
Kenta Arai, Thomas Wirth, Rapid Electrochemical Deprotection of the Isonicotinyloxycarbonyl Group from Carbonates and Thiocarbonates in a Microfluidic Reactor Org. Process Res. Dev. 2014, 18, pp.1377-1381.
Kenta Arai, Kevin Watts, Thomas Wirth, Difluoro- and Trifluoromethylation of Electron-deficient Alkenes in an Electrochemical Microreactor. ChemistryOpen, 2014, 3, pp.23-28.
Toshiki Takei, Yoshiko Urabe, Yuya Asahina, Hironobu Hojo, Takeshi Nomura, Kenichi Dedachi, Kenta Arai, Michio Iwaoka,Model, Study Using Designed Selenopeptides on the Importance of the Catalytic Triad for the Antioxidative Functions of Glutathione Peroxidase. J. Phys. Chem. B, 2014, 118, pp.492-500.

2013

Kenta Arai, Wataru Shibagaki, Reina Shinozaki, Michio Iwaoka, Reinvestigation of the Oxidative Folding Pathways of Hen Egg White Lysozyme: Switching of the Major Pathways by Temperature Control. Int. J. Mol. Sci., 2013, 14, pp.13194-13212.
Kenta Arai, Masato Noguchi, Beena G. Singh, K. Indira Priyadarsini, Katsuhiko Fujio, Yurika Kubo, Kyoko Takayama, Setsuko Ando, Michio Iwaoka, A Water-Soluble Selenoxide Reagent as a Useful Probe for the Reactivity and Folding of Polythiol Peptides. FEBS Open Bio, 2013, 3, pp.55–64.
岩岡道夫、荒井堅太「セレノタンパク質のフォールディング―ジセレニド結合を利用した効率的なフォールディングへの新手法」、化学同人、化学、一月号、pp. 66～67、2013年1月
Michio Iwaoka, Kenta Arai, From Sulfur to Selenium. A New Research Arena in Chemical Biology and Biological Chemistry. Curr. Chem. Biol., 2013, 7, pp.2-24. (DOI: 10.2174/2212796811307010002)

2012

Kenta Arai, Fumio Kumakura, Michio Iwaoka, Kinetic and Thermodynamic Analysis of the Conformational Folding Process of SS-Reduced Bovine Pancreatic Ribonuclease A Using a Selenoxide Reagent with High Oxidizing Ability. FEBS Open Bio, 2012, 2, pp.60-70.

2011

Sari Yoshida, Fumio Kumakura, Itsuki Komatsu, Kenta Arai, Yuko Onuma, Hironobu Hojo,* Beena G. Singh, K. Indira Priyadarsini, and Michio Iwaoka, Antioxidative Glutathione Peroxidase Activity of Selenoglutathione, Angew. Chem. Int. Ed. 2011, 50, pp. 2125–2128.
Kenta Arai, Kenichi Dedachi, Michio Iwaoka,* Rapid and Quantitative Disulfide Bond Formation for a Polypeptide Chain Using a Cyclic Selenoxide Reagent in an Aqueous Medium. Chem. Eur. J., 2011, 17, pp.481–485. (selected as VIP and Cover picture) (DOI: 10.1002/chem.201002742)

2010

Kenta Arai, Fumio Kumakura, Michio Iwaoka, Characterization of Kinetic and Thermodynamic Phases in the Pre-Folding Process of Bovine Pancreatic Ribonuclease A Coupled with Fast SS Formation and SS Reshuffling. Biochemistry, 2010, 49, pp.10535–10542.

Cover Gallery

Shunsuke Tsukagoshi, Rumi Mikami, Kenta Arai*, Basic amino acid conjugates of 1,2‐diselenan‐4‐amine with protein disulfide isomerase‐like functions as a manipulator of protein quality control, Chem Asian J. 2020, 15, pp. 2646–2652. (Selected as Very Important Paper and front cover picture)

Rumi Mikami, Shunsuke Tsukagoshi, Yoshiki Oda, Kenta Arai*, S-Denitrosylase-like Activity of Cyclic Diselenides Conjugated with Xaa-His Dipeptide: Role of Proline Spacer as a Key Activity Booster. ChemBioChem, 2022, e202100394. in press. (DOI: 10.1002/cbic.202100394) (Selected as front cover picture)

Yuya Nishizawa,† Yuri Satoh,† Osamu Kanie and Kenta Arai*, Resin-supported cyclic telluride as a heterogeneous promoter of disulfide formation under solid–liquid biphasic conditions, New J. Chem. 2023, 47, 18537-18546 (†equal contribution) (DOI: 10.1039/D3NJ02646A) (Selected as front cover picture).

Kenta Arai, Takahiko Matsunaga, Haruhito Ueno, Nozomi Akahoshi, Yuumi Sato, Gaurango Chakrabarty, Govindasamy Mugesh, Michio Iwaoka Modeling Thioredoxin Reductase-like Activity Using Cyclic Selenenyl Sulfides: Participation of an NH...Se Hydrogen Bond through Stabilization of the Mixed Se–S Intermediate. Chem. Eur. J. 2019,25,pp. 12751–12760.

Kenta Arai,* Yuui Osaka, Masahiro Haneda, Yuumi Sato, Cyclic telluride reagents with remarkable glutathione peroxidase-like activity for purification-free synthesis of highly pure organodisulfides, Catal. Sci. Technol., 2019, 9, pp. 3647-3655. (selected as backcover picture of the issue)

Kenta Arai, Kenji Moriai, Akinobu Ogawa, Michio Iwaoka, An Amphiphilic Selenide Catalyst Behaves Like a Hybrid Mimic of Protein Disulfide Isomerase and Glutathione Peroxidase 7. Chem. Asian J., 2014, 9, pp.3464-3471. (selected as backcover picture of the issue)

Kenta Arai, Kenichi Dedachi, Michio Iwaoka
Rapid and Quantitative Disulfide Bond Formation for a Polypeptide Chain Using a Cyclic Selenoxide Reagent in an Aqueous Medium. Chem. Eur. J., 2011, 17, pp.481–485. (selected as VIP and Front-Cover picture)

東海大学　理学部　化学科
東海大学　先進生命科学研究所

荒井　堅太　研究室

～生物物理化学、生命化学、有機合成化学～

Cover Gallery

Shunsuke Tsukagoshi, Rumi Mikami, Kenta Arai*, Basic amino acid conjugates of 1,2‐diselenan‐4‐amine with protein disulfide isomerase‐like functions as a manipulator of protein quality control, Chem Asian J. 2020, 15, pp. 2646–2652. (Selected as Very Important Paper and front cover picture)

Kenta Arai,* Yuui Osaka, Masahiro Haneda, Yuumi Sato, Cyclic telluride reagents with remarkable glutathione peroxidase-like activity for purification-free synthesis of highly pure organodisulfides, Catal. Sci. Technol., 2019, 9, pp. 3647-3655. (selected as backcover picture of the issue)

Kenta Arai, Kenji Moriai, Akinobu Ogawa, Michio Iwaoka, An Amphiphilic Selenide Catalyst Behaves Like a Hybrid Mimic of Protein Disulfide Isomerase and Glutathione Peroxidase 7. Chem. Asian J., 2014, 9, pp.3464-3471. (selected as backcover picture of the issue)

Kenta Arai, Kenichi Dedachi, Michio Iwaoka
Rapid and Quantitative Disulfide Bond Formation for a Polypeptide Chain Using a Cyclic Selenoxide Reagent in an Aqueous Medium. Chem. Eur. J., 2011, 17, pp.481–485. (selected as VIP and Front-Cover picture)

Cover Gallery

Kenta Arai,* Yuui Osaka, Masahiro Haneda, Yuumi Sato, Cyclic telluride reagents with remarkable glutathione peroxidase-like activity for purification-free synthesis of highly pure organodisulfides, Catal. Sci. Technol., 2019, 9, pp. 3647-3655. (selected as backcover picture of the issue)

Kenta Arai, Kenji Moriai, Akinobu Ogawa, Michio Iwaoka, An Amphiphilic Selenide Catalyst Behaves Like a Hybrid Mimic of Protein Disulfide Isomerase and Glutathione Peroxidase 7. Chem. Asian J., 2014, 9, pp.3464-3471. (selected as backcover picture of the issue)

Kenta Arai, Kenichi Dedachi, Michio Iwaoka Rapid and Quantitative Disulfide Bond Formation for a Polypeptide Chain Using a Cyclic Selenoxide Reagent in an Aqueous Medium. Chem. Eur. J., 2011, 17, pp.481–485. (selected as VIP and Front-Cover picture)

Kenta Arai, Kenichi Dedachi, Michio Iwaoka
Rapid and Quantitative Disulfide Bond Formation for a Polypeptide Chain Using a Cyclic Selenoxide Reagent in an Aqueous Medium. Chem. Eur. J., 2011, 17, pp.481–485. (selected as VIP and Front-Cover picture)