研究業績 / List of publications
2023
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Kenta Arai,*† Masaki Okumura,† Young-Ho Lee,† Hidekazu Katayama, Kenji Mizutani, Yuxi Lin, Sam-Yong Park, Kaichiro Sawada, Masao Toyoda, Hironobu Hojo, Kenji Inaba, Michio Iwaoka*, Diselenide-bond replacement of the external disulfide bond of insulin increases its oligomerization leading to sustained activity, Commun. Chem., 2023, 6, Article number: 258 (†equal contribution) (DOI: 10.1038/s42004-023-01056-4)
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Yuya Nishizawa,† Yuri Satoh,† Osamu Kanie and Kenta Arai*, Resin-supported cyclic telluride as a heterogeneous promoter of disulfide formation under solid–liquid biphasic conditions, New J. Chem. 2023, 47, 18537-18546 (†equal contribution) (DOI: 10.1039/D3NJ02646A) (Selected as front cover picture).
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Shunsuke Okada,† Yosuke Matsumoto,† Rikana Takahashi, Kenta Arai, Shingo Kanemura, Masaki Okumura*, Takahiro Muraoka*, Semi-enzymatic acceleration of oxidative protein folding by N-methylated heteroaromatic thiols, Chem. Sci. 2023, 14, 7630-7636 (†equal contribution) (DOI: 10.1039/D3SC01540H).
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佐藤有里、荒井堅太*. （総説）インスリンスーパーファミリーに属するヒトリラキシン-２の生理機能と応用。東海大学先進生命科学研究所2022年度紀要 受理済み。
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Kenta Arai*, Haruka Toba, Nozomi Yamamoto, Mao Ito, Rumi Mikami, Modeling Type-1 Iodothyronine Deiodinase with Peptide-Based Aliphatic Diselenides: Potential Role of Highly Conserved His and Cys Residues as a General Acid Catalyst. Chem. Eur. J, 2023, 29, e202202387 (DOI: 10.1002/chem.202202387) (Selected as Hot Paper)
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Small Organoselenium Catalysts as a Potential Manipulator for Redox Homeostasis and Proteostasis. Kenta Arai, Chapter 25 in Chalcogen Chemistry: Fundamentals and Applications, edited by V. Lippolis, C. Santi, Eder J. L. and A. L. Braga. The Royal Society of Chemistry, pp. 648-65 (DOI: 10.1039/BK9781839167386-00648).
2022
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Kenta Arai*, Rumi Mikami, Redox Chemistry of Selenols and Diselenides as Potential Manipulators for Structural Maturation of Peptides and Proteins, Metallomics Res., 2022, 2, rev1-17. (Open Access)
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Rumi Mikami, Shunsuke Tsukagoshi, Yoshiki Oda, Kenta Arai*, S-Denitrosylase-like Activity of Cyclic Diselenides Conjugated with Xaa-His Dipeptide: Role of Proline Spacer as a Key Activity Booster. ChemBioChem, 2022, e202100394. (DOI: 10.1002/cbic.202100394) (Selected as front cover picture)
2021
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Rumi Mikami, Shunsuke Tsukagoshi, Kenta Arai*, Abnormal Enhancement of Protein Disulfide Isomerase-like Activity of a Cyclic Diselenide Conjugated with a Basic Amino Acid by Inserting a Glycine Spacer. Biology, 2021, 10, 1090. (DOI: 10.3390/biology10111090)
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Kenta Arai*, Yuumi Sato, Ikumi Nakajima, Manami Saito, Moeka Sasaki, Akiko Kanamori, Michio Iwaoka, Glutathione peroxidase-like functions of 1,2-diselenane-4,5-diol and its amphiphilic derivatives: Switchable catalytic cycles depending on peroxide substrates, Bioorg. Med. Chem., 2021, 29, 115866.
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Kenta Arai, Michio Iwaoka* Flexible Folding: Disulfide-Containing Peptides and Proteins Choose the Pathway Depending on the Environments, Molecules, 2021, 26(1), 195.
Cover Gallery
Kenta Arai, Takahiko Matsunaga, Haruhito Ueno, Nozomi Akahoshi, Yuumi Sato, Gaurango Chakrabarty, Govindasamy Mugesh*, Michio Iwaoka* Modeling Thioredoxin Reductase-like Activity Using Cyclic Selenenyl Sulfides: Participation of an NH...Se Hydrogen Bond through Stabilization of the Mixed Se–S Intermediate. Chem. Eur. J. 2019,25,pp. 12751–12760.
Shunsuke Tsukagoshi, Rumi Mikami, Kenta Arai*, Basic amino acid conjugates of 1,2‐diselenan‐4‐amine with protein disulfide isomerase‐like functions as a manipulator of protein quality control, Chem Asian J. 2020, 15, pp. 2646–2652. (Selected as Very Important Paper and front cover picture)
Rumi Mikami, Shunsuke Tsukagoshi, Yoshiki Oda, Kenta Arai*, S-Denitrosylase-like Activity of Cyclic Diselenides Conjugated with Xaa-His Dipeptide: Role of Proline Spacer as a Key Activity Booster. ChemBioChem, 2022, e202100394. in press. (DOI: 10.1002/cbic.202100394) (Selected as front cover picture)
Kenta Arai,* Yuui Osaka, Masahiro Haneda, Yuumi Sato, Cyclic telluride reagents with remarkable glutathione peroxidase-like activity for purification-free synthesis of highly pure organodisulfides, Catal. Sci. Technol., 2019, 9, pp. 3647-3655. (selected as backcover picture of the issue)
Kenta Arai, Kenji Moriai, Akinobu Ogawa, Michio Iwaoka, An Amphiphilic Selenide Catalyst Behaves Like a Hybrid Mimic of Protein Disulfide Isomerase and Glutathione Peroxidase 7. Chem. Asian J., 2014, 9, pp.3464-3471. (selected as backcover picture of the issue)
