研究業績 / List of publications
2024
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Rumi Mikami, Yuya Nishizawa, Yuki Iwata, Shingo Kanemura, Masaki Okumura*, Kenta Arai*, ER Oxidoreductin 1-Like Activity of Cyclic Diselenides Drives Protein Disulfide Isomerase in an Electron Relay System, ChemBioChem, 2024, in press. (DOI: 10.1002/cbic.202400739)
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Yuri Satoh, Yosuke Ono, Rikana Takahashi, Hidekazu Katayama, Michio Iwaoka, Osamu Yoshino and Kenta Arai*, Seleno-relaxin analogues: Effect of internal and external diselenide bonds on the foldability and a fibrosis-related factor of endometriotic stromal cells, RSC. Chem. Biol., 2024, 5, 729-737. (DOI: 10.1039/D4CB00095A)
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Tsubura Kuramochi, Yukino Yamashita, Kenta Arai, Shingo Kanemura, Takahiro Muraoka* and Masaki Okumura*, Boosting the enzymatic activity of CxxC motif-containing PDI family members, Chem. Commun., 2024, in press. (DOI:10.1039D4CC01712A)
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三神瑠美、荒井堅太*,(総説)生体酵素が指し示す酸化的フォールディング触媒の設計指針。東海大学先進生命科学研究所2023年度紀要, 2024, 8, 26-31.
2023
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Kenta Arai,*† Masaki Okumura,† Young-Ho Lee,† Hidekazu Katayama, Kenji Mizutani, Yuxi Lin, Sam-Yong Park, Kaichiro Sawada, Masao Toyoda, Hironobu Hojo, Kenji Inaba, Michio Iwaoka*, Diselenide-bond replacement of the external disulfide bond of insulin increases its oligomerization leading to sustained activity, Commun. Chem., 2023, 6, Article number: 258 (†equal contribution) (DOI: 10.1038/s42004-023-01056-4)
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Yuya Nishizawa,† Yuri Satoh,† Osamu Kanie and Kenta Arai*, Resin-supported cyclic telluride as a heterogeneous promoter of disulfide formation under solid–liquid biphasic conditions, New J. Chem. 2023, 47, 18537-18546 (†equal contribution) (DOI: 10.1039/D3NJ02646A) (Selected as front cover picture).
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Shunsuke Okada,† Yosuke Matsumoto,† Rikana Takahashi, Kenta Arai, Shingo Kanemura, Masaki Okumura*, Takahiro Muraoka*, Semi-enzymatic acceleration of oxidative protein folding by N-methylated heteroaromatic thiols, Chem. Sci. 2023, 14, 7630-7636 (†equal contribution) (DOI: 10.1039/D3SC01540H).
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佐藤有里、荒井堅太*. (総説)インスリンスーパーファミリーに属するヒトリラキシン-2の生理機能と応用。東海大学先進生命科学研究所2022年度紀要, 2023, 7, 1-6.
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Kenta Arai*, Haruka Toba, Nozomi Yamamoto, Mao Ito, Rumi Mikami, Modeling Type-1 Iodothyronine Deiodinase with Peptide-Based Aliphatic Diselenides: Potential Role of Highly Conserved His and Cys Residues as a General Acid Catalyst. Chem. Eur. J, 2023, 29, e202202387 (DOI: 10.1002/chem.202202387) (Selected as Hot Paper)
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Small Organoselenium Catalysts as a Potential Manipulator for Redox Homeostasis and Proteostasis. Kenta Arai, Chapter 25 in Chalcogen Chemistry: Fundamentals and Applications, edited by V. Lippolis, C. Santi, Eder J. L. and A. L. Braga. The Royal Society of Chemistry, pp. 648-65 (DOI: 10.1039/BK9781839167386-00648).
2022
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Kenta Arai*, Rumi Mikami, Redox Chemistry of Selenols and Diselenides as Potential Manipulators for Structural Maturation of Peptides and Proteins, Metallomics Res., 2022, 2, rev1-17. (Open Access)
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Rumi Mikami, Shunsuke Tsukagoshi, Yoshiki Oda, Kenta Arai*, S-Denitrosylase-like Activity of Cyclic Diselenides Conjugated with Xaa-His Dipeptide: Role of Proline Spacer as a Key Activity Booster. ChemBioChem, 2022, e202100394. (DOI: 10.1002/cbic.202100394) (Selected as front cover picture)
2021
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Rumi Mikami, Shunsuke Tsukagoshi, Kenta Arai*, Abnormal Enhancement of Protein Disulfide Isomerase-like Activity of a Cyclic Diselenide Conjugated with a Basic Amino Acid by Inserting a Glycine Spacer. Biology, 2021, 10, 1090. (DOI: 10.3390/biology10111090)
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Kenta Arai*, Yuumi Sato, Ikumi Nakajima, Manami Saito, Moeka Sasaki, Akiko Kanamori, Michio Iwaoka, Glutathione peroxidase-like functions of 1,2-diselenane-4,5-diol and its amphiphilic derivatives: Switchable catalytic cycles depending on peroxide substrates, Bioorg. Med. Chem., 2021, 29, 115866.
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Kenta Arai, Michio Iwaoka* Flexible Folding: Disulfide-Containing Peptides and Proteins Choose the Pathway Depending on the Environments, Molecules, 2021, 26(1), 195.