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研究業績 / List of publications

2024

  • Rumi Mikami,  Yuya Nishizawa,  Yuki Iwata,  Shingo Kanemura,  Masaki Okumura*,  Kenta Arai*, ER Oxidoreductin 1-Like Activity of Cyclic Diselenides Drives Protein Disulfide Isomerase in an Electron Relay System, ChemBioChem, 2024, in press. (DOI: 10.1002/cbic.202400739)

  • Yuri Satoh, Yosuke Ono, Rikana Takahashi, Hidekazu Katayama, Michio Iwaoka, Osamu Yoshino and Kenta Arai*, Seleno-relaxin analogues: Effect of internal and external diselenide bonds on the foldability and a fibrosis-related factor of endometriotic stromal cells, RSC. Chem. Biol., 2024, 5, 729-737. (DOI: 10.1039/D4CB00095A)

  • Tsubura Kuramochi, Yukino Yamashita, Kenta Arai, Shingo Kanemura, Takahiro Muraoka* and Masaki Okumura*, Boosting the enzymatic activity of CxxC motif-containing PDI family members, Chem. Commun., 2024, in press. (DOI:10.1039D4CC01712A)

  • 三神瑠美、荒井堅太*,（総説）生体酵素が指し示す酸化的フォールディング触媒の設計指針。東海大学先進生命科学研究所2023年度紀要, 2024, 8, 26-31.  

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2023

  • Kenta Arai,*† Masaki Okumura,† Young-Ho Lee,† Hidekazu Katayama, Kenji Mizutani, Yuxi Lin, Sam-Yong Park, Kaichiro Sawada, Masao Toyoda, Hironobu Hojo, Kenji Inaba, Michio Iwaoka*, Diselenide-bond replacement of the external disulfide bond of insulin increases its oligomerization leading to sustained activity, Commun. Chem., 2023, 6, Article number: 258 (†equal contribution) (DOI: 10.1038/s42004-023-01056-4)

  • Yuya Nishizawa,† Yuri Satoh,† Osamu Kanie and Kenta Arai*, Resin-supported cyclic telluride as a heterogeneous promoter of disulfide formation under solid–liquid biphasic conditions, New J. Chem. 2023, 47, 18537-18546 (†equal contribution) (DOI: 10.1039/D3NJ02646A) (Selected as front cover picture).

  • Shunsuke Okada,† Yosuke Matsumoto,† Rikana Takahashi, Kenta Arai, Shingo Kanemura, Masaki Okumura*, Takahiro Muraoka*, Semi-enzymatic acceleration of oxidative protein folding by N-methylated heteroaromatic thiols, Chem. Sci. 2023, 14, 7630-7636 (†equal contribution) (DOI: 10.1039/D3SC01540H).

  • 佐藤有里、荒井堅太*. （総説）インスリンスーパーファミリーに属するヒトリラキシン-２の生理機能と応用。東海大学先進生命科学研究所2022年度紀要, 2023, 7, 1-6.

  • Kenta Arai*, Haruka Toba, Nozomi Yamamoto, Mao Ito, Rumi Mikami, Modeling Type-1 Iodothyronine Deiodinase with Peptide-Based Aliphatic Diselenides: Potential Role of Highly Conserved His and Cys Residues as a General Acid Catalyst. Chem. Eur. J, 2023, 29, e202202387 (DOI: 10.1002/chem.202202387) (Selected as Hot Paper)

  • Small Organoselenium Catalysts as a Potential Manipulator for Redox Homeostasis and Proteostasis. Kenta Arai, Chapter 25 in Chalcogen Chemistry: Fundamentals and Applications, edited by V. Lippolis, C. Santi, Eder J. L. and A. L. Braga. The Royal Society of Chemistry, pp. 648-65 (DOI: 10.1039/BK9781839167386-00648).

 

2022

  • Kenta Arai*, Rumi Mikami, Redox Chemistry of Selenols and Diselenides as Potential Manipulators for Structural Maturation of Peptides and Proteins, Metallomics Res., 2022, 2, rev1-17. (Open Access)

  • Rumi Mikami, Shunsuke Tsukagoshi, Yoshiki Oda, Kenta Arai*,  S-Denitrosylase-like Activity of Cyclic Diselenides Conjugated with Xaa-His Dipeptide: Role of Proline Spacer as a Key Activity Booster. ChemBioChem, 2022, e202100394. (DOI: 10.1002/cbic.202100394) (Selected as front cover picture)

 

2021

  • Rumi Mikami, Shunsuke Tsukagoshi, Kenta Arai*, Abnormal Enhancement of Protein Disulfide Isomerase-like Activity of a Cyclic Diselenide Conjugated with a Basic Amino Acid by Inserting a Glycine Spacer. Biology, 2021, 10, 1090. (DOI: 10.3390/biology10111090)

  • Kenta Arai*, Yuumi Sato, Ikumi Nakajima, Manami Saito, Moeka Sasaki, Akiko Kanamori, Michio Iwaoka, Glutathione peroxidase-like functions of 1,2-diselenane-4,5-diol and its amphiphilic derivatives: Switchable catalytic cycles depending on peroxide substrates, Bioorg. Med. Chem., 2021, 29, 115866.

  • Kenta Arai, Michio Iwaoka* Flexible Folding: Disulfide-Containing Peptides and Proteins Choose the Pathway Depending on the Environments, Molecules, 2021, 26(1), 195.

Cover Gallery

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Yuya Nishizawa,† Yuri Satoh,† Osamu Kanie and Kenta Arai*, Resin-supported cyclic telluride as a heterogeneous promoter of disulfide formation under solid–liquid biphasic conditions, New J. Chem. 2023, 47, 18537-18546 (†equal contribution) (DOI: 10.1039/D3NJ02646A) (Selected as front cover picture).

Rumi Mikami, Shunsuke Tsukagoshi, Yoshiki Oda, Kenta Arai*,  S-Denitrosylase-like Activity of Cyclic Diselenides Conjugated with Xaa-His Dipeptide: Role of Proline Spacer as a Key Activity Booster. ChemBioChem, 2022, e202100394. in press. (DOI: 10.1002/cbic.202100394) (Selected as front cover picture)

Shunsuke Tsukagoshi, Rumi Mikami, Kenta Arai*, Basic amino acid conjugates of 1,2‐diselenan‐4‐amine with protein disulfide isomerase‐like functions as a manipulator of protein quality control, Chem Asian J. 2020, 15, pp. 2646–2652. (Selected as Very Important Paper and front cover picture)

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Kenta Arai, Takahiko Matsunaga, Haruhito Ueno, Nozomi Akahoshi, Yuumi Sato, Gaurango Chakrabarty, Govindasamy Mugesh*, Michio Iwaoka* Modeling Thioredoxin Reductase-like Activity Using Cyclic Selenenyl Sulfides: Participation of an NH...Se Hydrogen Bond through Stabilization of the Mixed Se–S Intermediate. Chem. Eur. J. 2019,25,pp. 12751–12760.

Kenta Arai,* Yuui Osaka, Masahiro Haneda, Yuumi Sato,  Cyclic telluride reagents with remarkable glutathione peroxidase-like activity for purification-free synthesis of highly pure organodisulfides, Catal. Sci. Technol., 2019, 9, pp. 3647-3655. (selected as backcover picture of the issue) 

Kenta Arai, Kenji Moriai, Akinobu Ogawa, Michio Iwaoka, An Amphiphilic Selenide Catalyst Behaves Like a Hybrid Mimic of Protein Disulfide Isomerase and Glutathione Peroxidase 7. Chem. Asian J., 2014, 9, pp.3464-3471. (selected as backcover picture of the issue) 

Kenta Arai, Kenichi Dedachi, Michio Iwaoka
Rapid and Quantitative Disulfide Bond Formation for a Polypeptide Chain Using a Cyclic Selenoxide Reagent in an Aqueous Medium. Chem. Eur. J., 2011, 17, pp.481–485. (selected as VIP and Front-Cover picture) 

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