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2020

  • Osamu Yoshino*, Yosuke Ono, Masako Honda, Kyoko Hattori, Erina Sato, Takehiro Hiraoka, Masami Ito, Mutsumi Kobayashi, Kenta Arai, Hidekazu Katayama, Hiroyoshi Tsuchida, Kaori Yamada-Nomoto, Shunsuke Iwahata, Yoshiyuki Fukushi, Shinichiro Wada, Haruko Iwase, Kaori Koga, Yutaka Osuga, Michio Iwaoka and Nobuya Unno, Relaxin-2 May Suppress Endometriosis by Reducing Fibrosis, Scar Formation, and Inflammation, Biomedicines 2020, 8, 467. (Doi:10.3390/biomedicines8110467)

  • Shunsuke Tsukagoshi, Rumi Mikami, Kenta Arai*, Basic amino acid conjugates of 1,2‐diselenan‐4‐amine with protein disulfide isomerase‐like functions as a manipulator of protein quality control, Chem. Asian J. 2020, 15, 2646–2652. (Selected as Very Important Paper and front cover picture)

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2019

  • Kenta Arai, Takahiko Matsunaga, Haruhito Ueno, Nozomi Akahoshi, Yuumi Sato, Gaurango Chakrabarty, Govindasamy Mugesh*, Michio Iwaoka*, Modeling Thioredoxin Reductase-like Activity Using Cyclic Selenenyl Sulfides: Participation of an NH...Se Hydrogen Bond through Stabilization of the Mixed Se–S Intermediate, Chem. Eur. J., 2019,25,12751–12760.(Selected as Cover Feature of the issue)

  • Kenta Arai,* Yuui Osaka, Masahiro Haneda, Yuumi Sato,  Cyclic telluride reagents with remarkable glutathione peroxidase-like activity for purification-free synthesis of highly pure organodisulfides, Catal. Sci. Technol., 2019, 9, 3647-3655. (Selected as back-cover picture of the issue)

  • Shunsuke Okada†, Motonori Matsusaki†, Kenta Arai, Yuji Hidaka, Kenji Inaba, Masaki Okumura and Takahiro Muraoka*, Coupling effects of thiol and urea-type groups for promotion of oxidative protein folding, Chem. Commun., 2019, 5, 759-762.

  • Kenta Arai, Michio Iwaoka* Oxidative Protein Folding Using trans-3,4-Dihydroxyselenolane Oxide, Chapter 14 in Functional Disulfide Bonds, (Ed. Philip Hogg), Methods in Molecular Biology, Springer (2019).

 

2018

  • 荒井堅太、岩岡道夫「インスリンの高次構造形成過程の解明－インスリン製剤の簡便な化学合成への展開」公益社団法人日本薬学会、ファルマシア、54、1135-1139、pp. 1135-1139、2018年 12月

  • 荒井堅太、岩岡道夫「インスリンの簡便な化学合成法の開発－未来の糖尿病治療への期待」化学同人、化学、十月号、pp. 29～33、2018年10月

  • Kenta Arai†, Toshiki Takei†, Reina Shinozaki, Masato Noguchi, Shouta Fujisawa, Hidekazu Katayama, Luis Moroder, Setsuko Ando, Masaki Okumura, Kenji Inaba, Hironobu Hojo*, Michio Iwaoka*, Characterization and Optimization of Two-Chain Folding Pathways of Insulin via Native Chain Assembly, Communications Chemistry, 2018, 1, Article number: 26. †Contributed equally to this work

  • Kenta Arai, Haruhito Ueno, Yuki Asano, Gaurango Chakrabarty, Shingo Shimodaira, Govindasamy Mugesh*, Michio Iwaoka*, Protein Folding by Water-Soluble Cyclic Diselenides with Novel Oxidoreductase and Isomerase Activities. ChemBioChem, 2018, 19, 207-211.

  • Prachi Verma, Amit Kunwar, Kenta Arai, Michio Iwaoka, K. Indira Priyadarsini, Mechanism of radioprotection by dihydroxy-1-selenolane (DHS): Effect of fatty acid conjugation and role of glutathione peroxidase (GPx), Biochimie, 2018, pp. 122-133.

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2017

  • Michio Iwaoka*, Kenta Arai, Non-bonded Selenium•••Heteroatom Interactions in Selenoenzyme Glutathione Peroxidase and Mimics, Chapter 7 in Organoselenium Compounds in Biology and Medicine: Synthesis, Biological and Therapeutic Treatments, (Eds. Vimal Kumar Jain and K. Indira Priyadarsini), The Royal Society of Chemistry (2017).

  • Kenta Arai*, Setsura Ueda, Sayaka Tamura, Rapid Electrochemical Conversion of Thiol and Disulfide into Difluoro- and Trifluoromethyl Thioethers in a Microfluidic Reactor. Curr. Green Chem., 2017, 4, pp. 137–143.

  • Shingo Shimodaira, Yuki Asano, Kenta Arai, and Michio Iwaoka*, Selenoglutathione Diselenide: Unique Redox Reactions in the GPx-Like Catalytic Cycle and Repairing of Disulfide Bonds in Scrambled Protein, Biochemistry, 2017, 56, pp. 5644–5653.

  • 荒井堅太 「セレン原子が切り開く、インスリン化学合成と機能の向上を目指した新しい道筋」、Acadamist Journal、 (2017)（ウェブはこちらからアクセスできます。）

  • Kenta Arai†, Toshiki Takei†, Masaki Okumura†, Satoshi Watanabe†, Yuta Amagai, Yuya Asahina, Luis Moroder, Hironobu Hojo*, Kenji Inaba*, Michio Iwaoka* Preparation of Selenoinsulin as a Long-Lasting Insulin Analog, Angew. Chem. Int. Ed. 2017, 56, pp. 5522–5526.       †Contributed equally to this work

  • Kenta Arai*, Ayako Tashiro, Yuui Osaka, Michio Iwaoka*, Glutathione Peroxidase-Like Activity of Amino-SubstitutedWater-Soluble Cyclic Selenides: A Shift of the Major Catalytic Cycle in Methanol. Molecules, 2017, 22.

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2016

  • Prachi Verma, Amit Kunwar, Kenta Arai, Michio Iwaoka, K. Indira Priyadarsini, Alkyl chain modulated cytotoxicity and antioxidant activity of bioinspired amphiphilic selenolanes. Toxicol. Res. (Camb.), 2016, 5, pp. 434-445.

  • Kenta Arai, Michio Iwaoka, Tetrahydroselenophene. A Unique Structural Motif for Biochemical Applications. Curr. Org. Chem. 2016, 20, pp.155-165. (DOI: 10.2174/1385272819666150724233306 )

Cover Gallery

スライド1.PNG

Shunsuke Tsukagoshi, Rumi Mikami, Kenta Arai*, Basic amino acid conjugates of 1,2‐diselenan‐4‐amine with protein disulfide isomerase‐like functions as a manipulator of protein quality control, Chem Asian J. 2020, 15, pp. 2646–2652. (Selected as Very Important Paper and front cover picture)

cbic202100558-toc-0001-m.webp

Rumi Mikami, Shunsuke Tsukagoshi, Yoshiki Oda, Kenta Arai*,  S-Denitrosylase-like Activity of Cyclic Diselenides Conjugated with Xaa-His Dipeptide: Role of Proline Spacer as a Key Activity Booster. ChemBioChem, 2022, e202100394. in press. (DOI: 10.1002/cbic.202100394) (Selected as front cover picture)

Yuya Nishizawa,† Yuri Satoh,† Osamu Kanie and Kenta Arai*, Resin-supported cyclic telluride as a heterogeneous promoter of disulfide formation under solid–liquid biphasic conditions, New J. Chem. 2023, 47, 18537-18546 (†equal contribution) (DOI: 10.1039/D3NJ02646A) (Selected as front cover picture).

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Kenta Arai, Takahiko Matsunaga, Haruhito Ueno, Nozomi Akahoshi, Yuumi Sato, Gaurango Chakrabarty, Govindasamy Mugesh*, Michio Iwaoka* Modeling Thioredoxin Reductase-like Activity Using Cyclic Selenenyl Sulfides: Participation of an NH...Se Hydrogen Bond through Stabilization of the Mixed Se–S Intermediate. Chem. Eur. J. 2019,25,pp. 12751–12760.

裏表紙Te.PNG

Kenta Arai,* Yuui Osaka, Masahiro Haneda, Yuumi Sato,  Cyclic telluride reagents with remarkable glutathione peroxidase-like activity for purification-free synthesis of highly pure organodisulfides, Catal. Sci. Technol., 2019, 9, pp. 3647-3655. (selected as backcover picture of the issue) 

Kenta Arai, Kenji Moriai, Akinobu Ogawa, Michio Iwaoka, An Amphiphilic Selenide Catalyst Behaves Like a Hybrid Mimic of Protein Disulfide Isomerase and Glutathione Peroxidase 7. Chem. Asian J., 2014, 9, pp.3464-3471. (selected as backcover picture of the issue) 

Kenta Arai, Kenichi Dedachi, Michio Iwaoka
Rapid and Quantitative Disulfide Bond Formation for a Polypeptide Chain Using a Cyclic Selenoxide Reagent in an Aqueous Medium. Chem. Eur. J., 2011, 17, pp.481–485. (selected as VIP and Front-Cover picture) 

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